Tel (65) 6436 8574
Email iain.tan.b.h@singhealth.com.sg

Prof Iain Tan is Senior Consultant Medical Oncologist and the Deputy Division Chairman for the Division of Medical Oncology. He is a colorectal medical oncologist and NMRC clinician scientist-senior investigator awardee. His research spans translational research, clinical trials, and Public Health. He is a principal Investigator of the Laboratory of Applied Cancer Genomics at the Genome Institute of Singapore, A-Star, and faculty at CSCB, Duke-NUS. He is the clinical chair of Singapore’s colorectal cancer large collaborative grant program Colo-SCRIPT. A/Prof Iain collaborates widely with clinicians, scientists, and public health practitioners. He leads several data science efforts in Singhealth and is the platform lead for Tissue bank/Data & Population Health and Impact for Singapore Translational Cancer Consortium.

He is also the Deputy Group Chief Medical Informatics Officer (Research) for DGCIMIO (R), Singhealth. He supports GCMIO in advancing research informatics and accelerating the planning and implementation of clinical information systems, along with professional training and the development of clinical healthcare informatics staff to enhance clinical research activities. Additionally, he plays a crucial role in policy development and in overseeing the governance of clinical data within research. He also oversees platforms for data science research, innovation & implementation for NCCS as the director for Data & Digital Office. A firm believer in team science, together with his partners, he has published widely in top journals (e.g., Nature, Nature Genetics, JAMA, Cancer Discovery) in CRC, public health, and data science.

• NUS Saw Swee Hock School of Public Health (Joint Associate Professor)
• National Cancer Centre Singapore (Senior Consultant, Deputy Chairman – DMO, Director – NCCS Satellite STR Bank, Director – DDO)
• SingHealth (Deputy Group Chief Medical Informatics Officer (Research)
• Duke – NUS (Professor)
• Genome Institute of Singapore (Senior Clinician Scientist)

• Cancer Genomics & Immunotherapy
• Colorectal Cancer Biology
• Data science, Medical Informatics

• SingHealth residency programs
• Advisory/Mentoring roles in PhD Programmes

• Doctor of Philosophy, National University of Singapore, 2014
• Member, Royal College of Physicians UK, 2007
• Bachelor of Medicine, Bachelor of Surgery, National University of Singapore, 2002

• National Youth Award

• Senior Consultant Medical Oncologist, Division of Medical Oncology, National Cancer Centre Singapore
• Professor, Duke-NUS Graduate Medical School

• Deputy Chairman, Division of Medical Oncology, National Cancer Centre Singapore
• Deputy Group Chief Medical Informatics Officer (Research), SingHealth
• Director, Digital & Data Office, National Cancer Centre Singapore
• Director, NCCS Satellite STR Biobank
• Platform Lead for population health and impact (Platform 5) and cancer data basis and bio banking (Platform 2)
• Singapore Translational Cancer Consortium (STCC), Consortium for Clinical Research and Innovation Singapore. (CRIS)

• Simoni Yannick; Becht Etienne; Fehlings Michael; Loh Chiew Yee; Koo Si-Lin; Teng Karen Wei Weng; Yeong Joe Poh Sheng; Nahar Rahul; Zhang Tong; Kared Hassen; Duan Kaibo; Ang Nicholas; Poidinger Michael; Lee Yin Yeng; Larbi Anis; Khng Alexis J; Tan Emile; Fu Cherylin; Mathew Ronnie; Teo Melissa; Lim Wan Teck; Toh Chee Keong; Ong Boon-Hean; Koh Tina; Hillmer Axel M; Takano Angela; Lim Tony Kiat Hon; Tan Eng Huat; Zhai Weiwei; Tan Daniel S W; Tan Iain Beehuat; Newell Evan W
  Bystander CD8 T cells are abundant and phenotypically distinct in human tumour infiltrates. Nature 2018; 557(7706):575-579 JIF: 43.1
• Ignasius Joanito, Pratyaksha Wirapati, Nancy Zhao, Zahid Nawaz, Grace Yeo, Fiona Lee, Christine LP Eng, Dominique Camat Macalinao, Merve Kahraman, Harini Srinivasan, Vairavan Lakshmanan, Sara Verbandt, Petros Tsantoulis, Nicole Gunn, Prasanna Nori Venkatesh, Zhong Wee Poh, Rahul Nahar, Hsueh Ling Janice Oh , Loo Jia Min, Chia Shumei, Cheow Lih Feng, Elsie Cheruba, Michael Thomas Wong, Lindsay Kua, Clarinda Chua, Andy Nguyen, Justin Golovan, Anna Gan, Wan-Jun Lim, Yu Amanda Guo, Choon Kong Yap, Brenda Tay, Yourae Hong, Dawn Qingqing Chong, Aik-Yong Chok, Woong-Yang Park, Shuting Han, Meihuan Chang, Isaac Seow-En, Cherylin Fu, Ronnie Mathew, Ee-Lin Toh, Lewis Z Hong, Anders Jacobsen Skanderup, Ramanuj DasGupta, Chin-Ann Johnny Ong-, Kiat Hon Lim, Emile KW Tan, Si-Lin Koo, Wei Qiang Leow, Sabine Tejpar*, Shyam Prabhakar*, Iain Beehuat Tan*. *Co-corresponding author.
  Single-cell and bulk transcriptome sequencing identifies two epithelial tumour cell states and refines the consensus molecular classification of colorectal cancer Nat Genet. 2022 Jul;54(7):963-975. doi: 10.1038/s41588-022-01100-4. Epub 2022 Jun 30.
• Li Huipeng; Courtois Elise T; Sengupta Debarka; Tan Yuliana; Chen Kok Hao; Goh Jolene Jie Lin; Kong Say Li; Chua Clarinda; Hon Lim Kiat; Tan Wah Siew; Wong Mark; Choi Paul Jongjoon; Wee Lawrence J K; Hillmer Axel M; Tan Iain Beehuat*; Robson Paul*; Prabhakar Shyam* *Co-corresponding author
  Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors. Nature genetics 2017; 49(5):708-718 (Article; Published in Print)
• Deng Niantao; Goh Liang Kee; Wang Hannah; Das Kakoli; Tao Jiong; Tan Iain Beehuat; Zhang Shenli; Lee Minghui; Wu Jeanie; Lim Kiat Hon; Lei Zhengdeng; Goh Glenn; Lim Qing-Yan; Tan Angie Lay-Keng; Sin Poh Dianne Yu; Riahi Sudep; Bell Sandra; Shi Michael M; Linnartz Ronald; Zhu Feng; Yeoh Khay Guan; Toh Han Chong; Yong Wei Peng; Cheong Hyun Cheol; Rha Sun Young; Boussioutas Alex; Grabsch Heike; Rozen Steve; Tan Patrick
  A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets. Gut 2012; 61(5):673-84 JIF: 10.7
• Zang Zhi Jiang; Cutcutache Ioana; Poon Song Ling; Zhang Shen Li; McPherson John R; Tao Jiong; Rajasegaran Vikneswari; Heng Hong Lee; Deng Niantao; Gan Anna; Lim Kiat Hon; Ong Choon Kiat; Huang DaChuan; Chin Sze Yung; Tan Iain Bee-huat; Ng Cedric Chuan Young; Yu Willie; Wu Yingting; Lee Minghui; Wu Jeanie; Poh Dianne; Wan Wei Keat; Rha Sun Young; So Jimmy; Salto-Tellez Manuel; Yeoh Khay Guan; Wong Wai Keong; Zhu Yi-Jun; Futreal P Andrew; Pang Brendan; Ruan Yijun; Hillmer Axel M; Bertrand Denis; Nagarajan Niranjan; Rozen Steve; Teh Bin Tean; Tan Patrick
  Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodel-ing genes. Nature genetics 2012; 44(5):570-4 JIF: 35.2
• Lee Hae-Ock; Hong Yourae; Etlioglu Hakki Emre; Cho Yong Beom; Pomella Valentina; Van den Bosch Ben; Vanhecke Jasper; Verbandt Sara; Hong Hyekyung; Min Jae-Woong; Kim Nayoung; Eum Hye Hyeon; Qian Junbin; Boeckx Bram; Lambrechts Diether; Tsantoulis Petros; De Hertogh Gert; Chung Woosung; Lee Taeseob; An Minae; Shin Hyun-Tae; Joung Je-Gun; Jung Min-Hyeok; Ko Gunhwan; Wirapati Pratyaksha; Kim Seok Hyung; Kim Hee Cheol; Yun Seong Hyeon; Tan Iain Bee Huat; Ranjan Bobby; Lee Woo Yong; Kim Tae-You; Choi Jung Kyoon; Kim Young-Joon; Prabhakar Shyam; Tejpar Sabine; Park Woong-Yang
  Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer. Nature genetics 2020; 52(6):594-603, JIF: 38.3
• Chen HLR, Chong QD, Tay B, Zhou S, Wong EYT, Seow-En I, Tan KK, Wang Y, Seow A, Tan KE, Tan BHI, Tan SH
  Trends in Early-Onset Colorectal Cancer in Singapore: Epidemiological Study of a Multiethnic Population. JMIR Public Health Surveill 2025;11:e62835 doi: 10.2196/62835 PMID: 39725547, JIF: NA
• Guo YA, Tan A, Kulshrestha T, Chang MM, Lau D, Wang LY, Tay T, Kassam I, Revkov E, Rizzetto S, Tan I, Tan D, Skanderup A
  Abstract B040: Transcriptomic meta-analysis identifies robust, tissue-agnostic gene expression sig-nature of immune checkpoint blockade response. Cancer Immunology Research. 2025 Feb, 13. B040-B040. 10.1158/2326-6074.IO2025-B040. JIF: 8.1
• Zhu G, Rahman CR, Getty V, Odinokov D, Baruah P, Carrié H, Lim AJ, Guo YA, Poh ZW, Sim NL, Abdelmoneim A, Cai Y, Lakshmanan LN, Ho D, Thangaraju S, Poon P, Lau YT, Gan A, Ng S, Koo SL, Chong DQ, Tay B, Tan TJ, Yap YS, Chok AY, Ng MCH, Tan P, Tan D, Wong L, Wong PM, Tan IB, Skanderup AJ.
  A deep-learning model for quantifying circulating tumour DNA from the density distribution of DNA-fragment lengths. Nat Biomed Eng. 2025 Mar;9(3):307-319. doi: 10.1038/s41551-025-01370-3. Epub 2025 Mar 7. PMID: 40055581. JIF: 26.8
• Chia S, Wen Seow JJ, Peres da Silva R, Suphavilai C, Shirgaonkar N, Murata-Hori M, Zhang X, Yong EY, Pan J, Thangavelu MT, Periyasamy G, Yap A, Anand P, Muliaditan D, Chan YS, Siyu W, Yong CW, Hong N, Ran G, Sim NL, Guo YA, Yi Teh AX, Wei Ling CC, Wei Tan EK, Pei Cherylin FW, Chang M, Han S, Seow-En I, Chen Hui LR, Hsia Gan AH, Yap CK, Ng HH, Skanderup AJ, Chinswangwatanakul V, Riansuwan W, Trakarnsanga A, Pithukpakorn M, Tanjak P, Chaiboonchoe A, Park D, Kim DK, Iyer NG, Tsantoulis P, Tejpar S, Kim JE, Kim TI, Sampattavanich S, Tan IB, Na-garajan N, DasGupta R
  CAN-Scan: A multi-omic phenotype-driven precision oncology platform identifies prognostic bi-omarkers of therapy response for colorectal cancer. Cell Reports Medicine, 2025, 6(4), Article 102053. https://doi.org/10.1016/j.xcrm.2025.102053
  JIF: 11.7
• Tan IB, Tan C, Hsu LY, Dan YY, Aw A, Cook AR, Lee VJ.
  Prevalence and Outcomes of SARS-CoV-2 Infection Among Migrant Workers in Singapore. JA-MA. 2021 Feb 9;325(6):584-585. (Article; Published in Print)
  JIF: 56.3 Times cited: 36
• Tan WC, Tan JYJ, Lim JSJ, Tan RYC, Lee ARYB, Leong FL, Lee SC, Chai LYA, Tan TT, Malek MIBA, Ong B, Lye DC, Chiew CJ, Chng WJ, Lim ST, Bharwani LD, Tan IB, Sundar R, Tan KB.
  COVID-19 Severity and Waning Immunity After up to 4 mRNA Vaccine Doses in 73 608 Patients with Cancer and 621 475 Matched Controls in Singapore: A Nationwide Cohort Study. JAMA On-col. 2023 Jul 13. doi: 10.1001/jamaoncol.2023.2271. Online ahead of print. JIF: 9.3 Times cited: 0
• Tan RSYC, Lin Q, Low GH, Lin R, Goh TC, Chang CCE, Lee FF, Chan WY, Tan WC, Tey HJ, Leong FL, Tan HQ, Nei WL, Chay WY, Tai DWM, Lai GGY, Cheng LT, Wong FY, Chua MCH, Chua MLK, Tan DSW, Thng CH, Tan IBH, Ng HT.
  Inferring cancer disease response from radiology reports using large language models with data augmentation and prompting. J Am Med Inform Assoc. 2023 Jul 14:ocad133. doi: 10.1093/jamia/ocad133. Epub ahead of print. Times cited: 0
• D Ho, IBH Tan, M Motani
  Predictive models for colorectal cancer recurrence using multi-modal healthcare data
  Proceedings of the Conference on Health, Inference, and Learning, Pgs 204-213, doi: 10.1145/3450439.3451868
• Tay SB, Low GH, Wong GJE, Tey HJ, Leong FL, Li C, Chua MLK, Tan DSW, Thng CH, Tan IBH, Tan RSYC.
  Use of Natural Language Processing to Infer Sites of Metastatic Disease From Radiology Re-ports at Scale. JCO Clin Cancer Inform. 2024 May;8:e2300122. doi: 10.1200/CCI.23.00122. PMID: 38788166; PMCID: PMC11371090.