Email lampk@nus.edu.sg

I am a general medical doctor by training but then obtained a Ph.D. with a quantitative focus on developing clinical prediction models in dengue and have spent most of my research career working as a biostatistician. With colleagues at the Oxford University Clinical Research Unit in Vietnam, I conducted various collaborative works on dengue infection, ranging from observational studies to randomized clinical trials, to improve our understanding of the pathophysiology of dengue and the efficacy of different potential therapeutic options for dengue treatment. Since the COVID-19 outbreak, my research of interest has shifted to improving infectious disease surveillance and control by leveraging statistical and mathematical modeling methods and low-cost available public health data. At NUS, I will try my first attempt in this direction by exploring the possibility of using vaccine registries for surveillance purposes. This project is expected to provide a deeper understanding of the impact of vaccination coverage and delay on the risk of vaccine-preventable disease outbreaks and important features of effective strategies to prevent/mitigate this risk. This knowledge will inform the national plans to prevent and respond to vaccine-preventable disease outbreaks in countries worldwide.

• NUS Saw Swee Hock School of Public Health

• Development and validation of clinical prediction models
• Design and analysis of clinical trials
• Clinical aspects of infectious diseases, especially dengue infection
•  Mathematical modeling
• Vaccination
• Infectious disease surveillance and control

• Biostatistics
• Epidemiology

• PhD in Life and Biomolecular Sciences, Open University, UK (2015)
• General Medicine Doctor, University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam (2009)

• ASTMH/BMGF Annual Meeting Travel Award (2019

• Lecturer, Department of Epidemiology, University of Medicine and Pharmacy at Ho Chi Minh City (2020-2024)
• Postdoc Researcher, Biostatistics group, Oxford University Clinical Research Unit (2015-2020)
• PhD Student, Biostatistics group, Oxford University Clinical Research Unit (2011-2015)
• Research Assistant, Biostatistics group, Oxford University Clinical Research Unit (2010-2011)

• Zhao Y, Jalloh S, Phung KL, et al. (2023) Development and validation of a new measurement instrument to assess internship experience of medical doctors in low-income and middle-income countries. BMJ Glob Health; 8(11):e013399. DOI: https://doi.org/10.1136/bmjgh-2023-013399
• Rosenberger KD, Phung KL, Tobian F, et al. (2023) Early diagnostic indicators of dengue versus other febrile illnesses in Asia and Latin America (IDAMS study): a multicentre, prospective, observational study. Lancet Glob Health; 11(3):e361-e372. DOI: https://doi.org/10.1016/S2214-109X(22)00514-9
• Huynh TT, Phung KL, Ming DK, et al. (2022) The compensatory reserve index predicts recurrent shock in patients with severe dengue. BMC Med; 20(1):109. DOI: https://doi.org/10.1186/s12916-022-02311-6
• Nguyen LV, Phung KL, Damien KYM, et al. (2021). Combination of inflammatory and vascular markers in the febrile phase of dengue is associated with more severe outcomes. Elife; 10, e67460. DOI: https://doi.org/10.7554/eLife.67460
• Phung KL, McBride A, Le DHT, et al. (2020) Visual and Biochemical Evidence of Glycocalyx Disruption in Human Dengue Infection, and Association With Plasma Leakage Severity. Front Med (Lausanne); 7:545813. DOI: https://doi.org/10.3389/fmed.2020.545813
• Phan TQ, Phung KL, Truong HK, et al. (2019) Assessing the efficacy and safety of magnesium sulfate for management of autonomic nervous system dysregulation in Vietnamese children with severe hand foot and mouth disease. BMC Infect Dis; 19:737. DOI: https://doi.org/10.1186/s12879-019-4356-x
• Le TQN, Phung KL, Nguyen TVT, et al. (2018) Factors associated with a low prevalence of exclusive breastfeeding during hospital stay in urban and semi-rural areas of southern Vietnam. Int Breastfeed J; 13:46. DOI: https://doi.org/10.1186/s13006-018-0188-3
• Yacoub S, Phung KL, Huynh TT, et al. (2017) Endothelial nitric oxide pathways in the pathophysiology of dengue: a prospective observational study. Clin Infect Dis; 65(9):1453-61. DOI: https://doi.org/10.1093/cid/cix567
• Phung KL, Fidler S, Foster C (2017) A review of transition experiences in perinatally and behaviourally acquired HIV-1 infection; same, same but different? J Int AIDS Soc; 20(Suppl 3):91-9. DOI: https://doi.org/10.7448/IAS.20.4.21506
• Phung KL, Tran VN, Tran TTT, et al. (2017) The value of daily platelet counts for predicting dengue shock syndrome: Results from a prospective observational study of 2301 Vietnamese children with dengue. Plos Negl Trop Dis; 11(4):e0005498. DOI: https://doi.org/10.1371/journal.pntd.0005498
• Whitehorn J, Nguyen VVC, Phung KL, et al. (2015) Lovastatin for the Treatment of Adult Patients With Dengue: A Randomized, Double-Blind, Placebo-Controlled Trial. Clin Infect Dis; 62(4):468-76. DOI: https://doi.org/10.1093/cid/civ949
• Phung KL, Dong THT, Nguyen MD, et al. (2015) A Prognostic Model for Development of Profound Shock among Children Presenting with Dengue Shock Syndrome. PLoS ONE; 10(5):e0126134. DOI: https://doi.org/10.1371/journal.pone.0126134
• Phung KL, Huynh TT, Lubis IN, et al. (2015) Prognosis of neonatal tetanus in the modern management era: an observational study in 107 Vietnamese infants. Int J Infect Dis; 33:7-11. DOI: https://doi.org/10.1016/j.ijid.2014.12.011
• Phung KL, Dong THT, Tran VD, et al. (2013) Clinical Characteristics of Dengue Shock Syndrome in Vietnamese Children: A 10-Year Prospective Study in a Single Hospital. Clin Infect Dis; 57(11):1577-86. DOI: https://doi.org/10.1093/cid/cit594
• Nguyet MN, Tran NBC, Phung KL, et al. (2012) A Randomized, Double-Blind Placebo Controlled Trial of Balapiravir, a Polymerase Inhibitor, in Adult Dengue Patients. J Infect Dis; 207(9):1442-50. DOI: https://doi.org/10.1093/infdis/jis470