GHANI Azra

Professor

GHANI, Azra

In addition to my role at NUS, I am currently Academic Director of Imperial Global Singapore, Director of the MRC Centre for Global Infectious Disease Analysis and Chair in Infectious Disease Epidemiology at the School of Public Health, Imperial College London. I also hold a Visiting Professor appointment at LKC Medicine, NTU.

My research combines the use of mathematical models and statistical methods to understand the transmission dynamics and control of a range of infectious diseases of humans and animals. The focus of my research is applied, developing both simple compartmental models and more complex individual-based models, to explore the impact of interventions and to help guide policy. In the past I have worked on a wide range of infectious diseases, including BSE and vCJD, sexually transmitted infections and HIV. Over the last 15 years my research has focused on the development of models that can inform policies on how, where and when to implement different interventions against malaria to aid local elimination, and eventual eradication, of the parasite. I also have active research programmes in pandemic preparedness and outbreak response, building on past research in responding to the SARS, influenza and COVID-19 pandemics.

I am currently a member of the Coalition for Epidemic Preparedness Innovations (CEPI) Scientific Advisory Committee and previously served on the WHO Malaria Policy Advisory Group and the Gavi Vaccine Investment Strategy Steering Committee.

I am a Trustee for the Science Media Centre and was previously a Trustee for the international charity Malaria No More UK whose work I continue to support as a special advisor.

Affiliation

  • NUS Saw Swee Hock School of Public Health (Joint)
  • Imperial College London, School of Public Health (Primary)
  • Imperial Global Singapore (Primary)
  • NTU, LKC School of Medicine (Visiting)

Research Areas

  • Infectious disease epidemiology
  • Mathematical modelling
  • Malaria and vector-borne diseases
  • Vaccine preventable diseases
  • Outbreak response and pandemic preparedness

Teaching Areas

  • Epidemiology
  • Mathematical Modelling

Academic/Professional Qualifications

  • MA Mathematics, Newnham College, University of Cambridge (1989-1992)
  • MSc Operational Research, University of Southampton (1993)
  • PhD Biology, Imperial College London (1997)

Awards/Honours

  • Fellow of the UK Academy of Medical Sciences (2017)
  • Chalmers Medal, Royal Society of Tropical Medicine & Hygiene (2017)
  • Univer Colworth Prize, Microbiology Society (2021)
  • Member of the British Empire (MBE), 2021 Queen’s Birthday Honours

Career History

  • Professor in Infectious Disease Epidemiology, Imperial College London, 2007 – current
  • Reader (Associate Professor) in Infectious Disease Modelling, London School of Hygiene & Tropical Medicine, 2004-2007
  • Royal Society Dorothy Hodgkin Fellow, Imperial College London, 2000-2004
  • Wellcome Trust Research Fellow and Junior Research Fellow St Cross College, University of Oxford, 1997-2000
  • Research Assistant, Imperial College London, 1993-1996

Administrative Leadership

  • Director, MRC Centre for Global Infectious Disease Analysis, Imperial College London
  • Academic Director, Imperial Global Singapore

Professional/Consulting Activities

  • Scientific Advisory Board Member, Coalition for Epidemic Preparedness and Innovation (CEPI)
  • Trustee, Science Media Centre (UK)

Selected Publications

  • Schmit N, Topazian HM, Natama HM, Bellamy D, Traore O, Some MA, Rouamba T, Tahita MC, Bonko MDA, Sourabie A, Sorgho H, Stockdale L, Provstgaard-Morys S, Aboagye J, Woods D, Rapi K, Datoo MS, Lopez FR, Charles GD, McCain K, Ouedraogo JB, Hamaluba M, Olotu A, Dicko A, Tinto H, Hill AVS, Ewer KJ, Ghani AC, Winskill P (2024). The public health impact and cost-effectiveness of the R21/Matrix-M malaria vaccine: a mathematical modelling study. Lancet Infect Dis 24(5): 465-475.
  • Watson OJ, Barnsley G, Toor J, Hogan AB, Winskill P, Ghani AC (2022). Global impact of the first year of COVID-19 vaccination: a mathematical modelling study. Lancet Infectious Diseases 22(9): 1293-1302.
  • Hogan AB, Jewell BL, Sherrard-Smith E, Vesga JF, Watson OJ, Whittaker C, Hamlet A, Smith JA, Winskill P, Verity R, Baguelin M, Lees JA, Whittles LK, Ainslie KEC, Bhatt S, Boonyasiri A, Brazeau NF, Cattarino L, Cooper LV, Coupland H, Cuomo-Dannenburg G, Dighe A, Djaafara BA, Donnelly CA, Eaton JW, van Island SL, Fitzjohn RG, Fu H, Gaythorpe KAM, Green W, Haw DJ, Hayes S, Hinsley W, Imai N, Laydon DJ, Mangal TD, Mellan TA, Mishra S, Nedjati-Gilani G, Parag KV, Thompson HA, Unwin HJT, Vollmer MAC, Walters CE, Wang H, Wang Y, Xi X, Ferguson NM, Okell LC, Churcher TS, Arinaminpathy N, Ghani AC, Walker PGT, Hallett TB (2020). Potential impact of the COVID-19 pandemic on HIV, tuberculosis and malaria in low-income and middle-income countries: a modelling study. Lancet Global Health 8(9): e1132-e1141.
  • Sherrard-Smith E, Hogan AB, Hamlet A, Watson OJ, Whittaker C, Winskill P, Ali F, Mohammad AB, Uhomoibhi P, Maikore I, Ogbulafor N, Nikau J, Kont MD, Challenger JD, Verity R, Lambert B, Cairns M, Rao B, Baguelin M, Whittles LK, Lees JA, Bhatia S, Knock ES, Okell L, Slater HC, Ghani AC, Walker PGT, Okoko OO, Churcher TS (2020). The potential public health consequences of COVID-19 on malaria in Africa. Nature Medicine. 26(9): 1411-1416.
  • Verity R+, Okell LC+, Dorigatti I+, Winskill P, Whittaker C, Imai N, Cuomo-Dannenburg G, Thompson H, Walker PGT, Fu H, Dighe A, Griffin JT, Baguelin M, Bhatia S, Boonyasiri A, Cori A, Cucunuba Z, Fitzjohn R, Gaythorpe K, Green W, Hamlet A, Hinsley W, Laydon D, Nedjati-Gilani G, Riley S, van Elsand S, Volz E, Wang H, Wang Y, Xi X, Donnelly CA, Ghani AC*, Ferguson NM* (2020). Estimates of the severity of coronavirus disease 2019: a model-based analysis. Lancet Infectious Diseases 20(6): 669-677. + Joint first authors; *Joint corresponding authors.
  • Walker PGT, Whittaker C, Watson OJ, Baguelin M, Winskill P, Hamlet A, Djafaara BA, Cucunuba Z, Olivera Mesa D, Green W, Thompson H, Nayagam S, Ainslie KEC, Bhatia S, Bhatt S, Boonyasiri A, Boyd O, Brazeau NF, Cattarino L, Cuomo-Dannenburg G, Dighe A, Donnelly CA, Dorigatti I, van Elsand SL, FitzJohn R, Fu H, Gaythorpe K, Geidelberg L, Grassly N, Haw D, Hayes S, Hinsley W, Imai N, Jorgensen D, Knock E, Laydon D, Mishra S, Nedjati-Gilani G, Okell LC, Unwin HJ, Verity R, Vollmer M, Walters CE, Wang H, Wang Y, Xi X, Lalloo DG, Ferguson NM, Ghani AC (2020). The impact of COVID-19 and strategies for mitigation and suppression in low- and middle-income countries. Science 369(6502): 413-422.
  • Griffin JT, Bhatt S, Sinka ME, Gething PW, Lynch M, Patouillard E, Shutes E, Newman RD, Alonso P, Cibulskis RE, Ghani AC (2016). Potential for reduction of burden and local elimination of malaria by reducing Plasmodium falciparum malaria transmission: a mathematical modelling study. Lancet Infectious Diseases 16: 465-472.
  • White MT, Verity R, Griffin JT, Asante KP, Owusu-Agyei S, Greenwood B, Drakeley C, Gesase S, Lusingu J, Ansong D, Adjei S, Abednego T, Ogutu B, Otieno L, Otieno W, Agnandji S, Lell B, Kremsner P, Hoffman I, Martinson F, Kamthunzu P, Tinito H, Valea I, Sorgho H, Okeno M, Otieno K, Hamel M, Salim N, Mtoro A, Abdulla S, Aide P, Sacarlal J, Aponte J, Njuguna P, Marsh K, Bejon P, Riley EM, Ghani AC (2015). Immunogenicity of the RTS,S/AS01 malaria vaccine and implications for duration of vaccine efficacy: secondary analysis of data from a phase 3 randomised controlled trial. Lancet Infectious Diseases, 15: 1450-1458.
  • Penny MA, Verity R, Bever C, Sauboin C, Galactionova K, Flasche S, White MT, Wenger E, Van de Velde N, Pemberton-Ross P, Griffin JT, Smith TA, Eckhoff PA, Muhib F, Jit M, Ghani AC (2015). Public health impact and cost-effectiveness of the RTS,S/AS01 malaria vaccine: a systematic comparison of predictions from four mathematical models. Lancet, 387: 367-375.
  • Walker PG, White MT, Griffin JT, Reynolds A, Ferguson NM, Ghani AC (2015). Malaria morbidity and mortality in Ebola-affected countries caused by decreased health-care capacity, and the potential effect of mitigation strategies: a modelling analysis. Lancet Infectious Diseases, 15:825-832.
  • Walker PGT, ter Kuile FO, Garske T, Menendez C, Ghani AC (2014). Estimated risk of placental infection and low birthweight attributable to Plasmodium falciparum malaria in Africa in 2010: a modelling study. Lancet Global Health, 2(8): e460-467.
  • Okell LC, Bousema T, Griffin JT, Ouedraogo AL, Ghani AC, Drakeley CJ (2012). Factors determining the occurrence of submicroscopic malaria infections and their relevance for control. Nature Communications 3: 1237
  • Griffin JT, Hollingsworth TD, Okell L, Churcher TS, White MT, Hinsley W, Bousema T, Drakeley CJ, Ferguson NM, Basanez MG, Ghani AC (2010). Strategies to reduce P.falciparum malaria transmission in Africa using currently available tools. PLoS Medicine, 7(8): e1000324.
  • Garske T, Legrand J, Donnelly CA, Ward H, Fraser C, Cauchemez S, Ferguson NM, Ghani AC (2009). Assessing the severity of the novel A/H1N1 influenza pandemic. British Medical Journal 339 b2840.
  • Ghani AC, Donnelly CA, Cox DR, Griffin JT, Fraser C, Ho LM, Chan WS, Lam TH, Anderson RM, Hedley AJ, Leung G (2005). Methods for estimating the case fatality ratio for a novel emerging infectious disease. American Journal of Epidemiology 162: 1-8.
  • Ghani AC, Ferguson NM, Donnelly CA, Anderson RM (2000). Predicted vCJD mortality in Great Britain. Nature 406: 583-584.

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