Comparative effectiveness clinical trials in infectious diseases research – pitfalls and novel approaches

Date:

Tue, 25 July 2023

Time:

10am-11am [Singapore [GMT +8]

Location:

Seminar Room 2, Level 8
Tahir Foundation Building (MD1)
National University of Singapore
12 Science Drive 2, Singapore 117549

Details:

You are cordially invited to the ON-SITE SSHSPH Staff Research Round. We look forward to your attendance and we hope for an interesting discussion.

Refreshments will be provided at 9:30am, do drop by to hang out for a bit before the session starts.

We will also be having a Lucky Draw at the end of the session, register yourself and stand a chance to win a special prize!
*Only Attendees will be included in the Lucky draw*

Abstract:

Comparative effectiveness trials compare different established standards of care, for example different antibiotic choices or durations. The non-inferiority trial design is commonly used in infectious diseases research, but there are several methodologic issues and potential pitfalls that need to be carefully thought about when conducting a non-inferiority trial. Novel approaches such as ordinal outcomes and the DOOR/RADAR design may be useful alternatives, but come with their own issues.

Speakers:

Dr Sean Ong
Infectious Diseases Physician, Joint PhD Program, University of Toronto- University of Melbourne

Dr Ong is an infectious diseases physician who completed his specialist training in Singapore in 2022. He was actively involved in clinical research throughout the COVID-19 pandemic, spearheading several local observational studies and played a key role as site investigator in several large international multicentre RCTs. After completing his specialty training, he enrolled in a unique joint PhD program with the University of Toronto in Canada and the University of Melbourne in Australia, working with the BALANCE and SNAP trial networks, which are the two largest RCTs in bloodstream infections to date. His PhD research focuses on investigating different approaches to optimising the design, delivery, and analysis of clinical trials, with a focus on bloodstream infections.