Tai E Shyong

Professor (Joint)

Tel (65) 6772 4371
Email tai_e_shyong@nuhs.edu.sg

TAI E Shyong

Affiliation

  • NUS Saw Swee Hock School of Public Health (Joint)
  • Senior Consultant, Division of Endocrinology, National University Hospital (Primary)

Research Areas

  • Elucidation of gene-environment interactions that determine the levels of cardiovascular risk factors in the Singapore population, the role of genetic and environmental factors that alter lipid and lipoprotein metabolism as well as insulin resistance.
  • Implementation and evaluation of novel models of healthcare delivery that can improve the efficiency of the healthcare system in order to optimise outcomes for patients for a given healthcare budget. These include efforts to provide better integration and coordination of care between healthcare institutions, greater use of telecollaboration and telehealth and the use of analytics to drive health care quality

Teaching Areas

  • Genetics of complex diseases
  • Burden of obesity
  • Diabetes and cardiovascular disease
  • Pathophysiology of obesity
  • Diabetes and cardiovascular disease treatment and prevention of diabetes and dyslipidemia

Academic/Professional Qualifications

  • MB ChB (with commendation)
  • MRCP (UK)
  • FRCP
  • PhD

Awards/Honours

  • Clinician Scientist Investigator Award 2005-2008
  • Clinician Scientist Award (Senior Investigator) 2009-2014

Career History

  • 1/8/90-31/10/90 House officer General medicine, Royal Devon and Exeter (Wonford) Hospital
  • 1/11/90-31/1/91 House officer Acute Geriartrics, Royal Devon and Exeter (Heavitree) Hospital
  • 1/2/91-30/4/91 House officer General Surgery, Ninewells Hospital, Dundee
  • 1/5/91-31/7/91 House officer Dundee Royal Infirmary
  • 28/8/91-27/8/93 Medical Officer Republic of Singapore Navy
  • 1/9/93-31/12/93 Medical Officer Medical Unit I, Singapore General Hospital (SGH)
  • 1/1/94-31/3/94 Medical Officer Haematology, SGH
  • 1/4/94-30/4/94 Medical Officer Medical oncology, SGH
  • 1/5/94-31/8/94 Medical Officer Medical Unit III, SGH
  • 1/9/94-31/12/94 Medical Officer Cardiology, SGH
  • 1/1/95-30/4/95 Medical Officer Medical Unit II, SGH
  • 1/5/95-31/10/95 Medical Officer Accident and Emergency, SGH
  • 1/11/95-30/4/96 Medical Officer Endocrinology, SGH
  • 1/5/97-31/8/96 Medical Officer Rheumatology and Immunology, TTSH
  • 1/9/96 to 31/5/00 Registrar Endocrinology, SGH
  • 1/6/00 to 31/12/01 Senior Registrar Endocrinology, SGH
  • 1/1/01 to 31/3/02 Associate Consultant Endocrinology, SGH
  • 1/4/02-10/5/2009 Consultant Endocrinology, SGH
  • 11/5/2009-present Associate Professor Medicine, NUS

Administrative Leadership

  • Head, Division of Endocrinology, Department of Medicine, National University Hospital

Selected Publications

  • Meta-analysis identifies common variants associated with body mass index in east Asians. Wen W, Cho YS, Zheng W, Dorajoo R, Kato N, Qi L, Chen CH, Delahanty RJ, Okada Y, Tabara Y, Gu D, Zhu D, Haiman CA, Mo Z, Gao YT, Saw SM, Go MJ, Takeuchi F, Chang LC, Kokubo Y, Liang J, Hao M, Le Marchand L, Zhang Y, Hu Y, Wong TY, Long J, Han BG, Kubo M, Yamamoto K, Su MH, Miki T, Henderson BE, Song H, Tan A, He J, Ng DP, Cai Q, Tsunoda T, Tsai FJ, Iwai N, Chen GK, Shi J, Xu J, Sim X, Xiang YB, Maeda S, Ong RT, Li C, Nakamura Y, Aung T, Kamatani N, Liu JJ, Lu W, Yokota M, Seielstad M, Fann CS; Genetic Investigation of ANthropometric Traits (GIANT) Consortium, Wu JY, Lee JY, Hu FB, Tanaka T, Tai ES, Shu XO. Nat Genet. 2012 Feb 19;44(3):307-11. doi: 10.1038/ng.1087.
  • Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Cho YS, Chen CH, Hu C, Long J, Ong RT, Sim X, Takeuchi F, Wu Y, Go MJ, Yamauchi T, Chang YC, Kwak SH, Ma RC, Yamamoto K, Adair LS, Aung T, Cai Q, Chang LC, Chen YT, Gao Y, Hu FB, Kim HL, Kim S, Kim YJ, Lee JJ, Lee NR, Li Y, Liu JJ, Lu W, Nakamura J, Nakashima E, Ng DP, Tay WT, Tsai FJ, Wong TY, Yokota M, Zheng W, Zhang R, Wang C, So WY, Ohnaka K, Ikegami H, Hara K, Cho YM, Cho NH, Chang TJ, Bao Y, Hedman ÅK, Morris AP, McCarthy MI; DIAGRAM Consortium; MuTHER Consortium, Takayanagi R, Park KS, Jia W, Chuang LM, Chan JC, Maeda S, Kadowaki T, Lee JY, Wu JY, Teo YY, Tai ES, Shu XO, Mohlke KL, Kato N, Han BG, Seielstad M. Nat Genet. 2011 Dec 11;44(1):67-72. doi: 10.1038/ng.1019.
  • A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis. Lin Z, Bei JX, Shen M, Li Q, Liao Z, Zhang Y, Lv Q, Wei Q, Low HQ, Guo YM, Cao S, Yang M, Hu Z, Xu M, Wang X, Wei Y, Li L, Li C, Li T, Huang J, Pan Y, Jin O, Wu Y, Wu J, Guo Z, He P, Hu S, Wu H, Song H, Zhan F, Liu S, Gao G, Liu Z, Li Y, Xiao C, Li J, Ye Z, He W, Liu D, Shen L, Huang A, Wu H, Tao Y, Pan X, Yu B, Tai ES, Zeng YX, Ren EC, Shen Y, Liu J, Gu J. Nat Genet. 2011 Dec 4;44(1):73-7. doi: 10.1038/ng.1005.

Media Coverage

  • New drug may aid in cholesterol fight, The Straits Times, 29 September 2017
  • 基因可导致高血脂打针控制高胆固醇, Shin Min Daily News, 28 September 2017
  • Research on behaviour, targeted messaging may help Singapore’s war on diabetes: Experts, Channel NewsAsia, 31 August 2017
  • Couch potatoes, beware health risk, The Straits Times, Mind Your Body, 3 Nov 2015
Back to Faculty Directory