Vaccine-preventable diseases (VPD) are infectious diseases that can be prevented through vaccination. Vaccines are one of the most effective and cost-effective public health interventions, saving millions of lives each year. Vaccination protects individuals from contracting VPDs and reduces the spread of these diseases in the community. Our focus is on cost-effectiveness and intervention strategies of human papillomavirus (HPV) vaccination implementation, modelling of VPD in Singapore and countries in South East Asia.