Collaborative Solutions Targeting Antimicrobial Resistance Threats in Health Systems (CoSTAR-HS)
CoSTAR-HS has been funded for our proposed work to build up capacity, infrastructure and networking opportunities for AMR research in Singapore under the National Medical Research Council’s (NMRC’s) Centre Grant call in October 2016. It is a partnership involving researchers and clinicians from the National University Health System (NUHS), Singapore General Hospital (SGH), and Communicable Diseases Centre (CDC).
Research Strategy
Our research strategy is to strengthen institutional and national capability in the development, implementation and evaluation of novel solutions or policies targeting drug-resistant bacteria, especially carbapenem-resistant Enterobacteriaceae (CRE).
Our focused research areas are:
- Prevention of transmission of drug-resistant bacteria, in particular CRE.
- Early diagnosis and treatment of drug-resistant bacteria.
- Health systems drivers of AMR, and translation of research outcomes to healthcare solutions and policies.
Facility Cores (click here for more details on each Cores)
Research Themes (click here for more details on each research themes)
There are 8 research themes within CoSTAR-HS:
- Multiple Combination Bactericidal Test (MCBT) to guide XDR-GNB (especially CRE) treatment
- Novel diagnostics for the identification of Antimicrobial Resistant (AMR) determinants
- Novel infection control strategies assessment
- Optimizing antimicrobial stewardship programmes (ASPs) in Singapore
- Carbapenemase producing Enterobacteriaceae in Singapore (CaPES): Epidemiology, risk factors and outcomes
- Integration of whole genome sequencing (WGS) into infection control
- Combining shoe-leather epidemiology with WGS to model and predict CP-CRE transmission dynamics
- Health systems and behavioral science (HSBS) research to address the drivers of AMR in hospitals
SSHSPH Intranet (SSHSPH staff only)
