HomeAboutFaculty DirectoryYAMADA Yoshiyuki

YAMADA Yoshiyuki

I have studied about the development of the species identification/virulent strain typing methods for a variety of gram-negative and -positive bacterial fish pathogens by PCR/PCR-RFLP and DNA sequencing during my phD.

Since I moved to Singapore in 2000, I have learned the variety of techniques on molecular bacteriology/virology fields throughout the academic researches on pathogens such as tuberculosis, coronavirus and influenza viruses.

I'm recently back to the bacterial population genetics (tuberculosis) after joining SSHSPH in July 2018. Here, I would like to contribute more through a molecular biologist's points of view and to help strong connection between the laboratories and SSHSPH's computational bioinformaticians.

Affiliation:

  • NUS Saw Swee Hock School of Public Health

Research Areas:

  • Infectious Diseases
  • Epidemiology

Academic/Professional Qualifications:

  • phD (Agricultural and Life Sciences), University of Tokyo, Japan. 1999

Career History:

  • Research Fellow, Dept of Biological Sciences, National University of Singapore, 2000-2003
  • Senior Research Fellow, Institute of Molecular and Cell Biology, Singapore, 2004-2010
  • Research Scientist, Singapore-MIT Alliance in Research and Technology, Singapore 2010-2014
  • Research Fellow, Dept of Medicine, National University of Singapore, 2014-2018
  • Research Fellow, SSHSPH, National University of Singapore, 2018-present

Selected Publications:

  • Yang X, Wedajo W, Yamada Y, Dahlroth SL, Neo JJ, Dick T, Chui WK. 1,3,5-triazaspiro[5.5]undeca-2,4-dienes as selective Mycobacterium tuberculosis dihydrofolate reductase inhibitors with potent whole cell activity. Eur J Med Chem. 2018 144:262-276. [PMID: 29274493]
  • Zheng J, Yamada Y, Fung TS, Huang M, Chia R, Liu DX. Identification of N-linked glycosylation sites in the spike protein and their functional impact on the replication and infectivity of coronavirus infectious bronchitis virus in cell culture. Virology. 2018 513:65-74. [PMID: 29035787]
  • Yamada Y, Dick T. The Mycobacterial Caseinolytic Protease Gene Regulator ClgR is Substrate of Caseinolytic Protease. 2017 mSphere 2 (2): e00338-16. [PMID: 28317028]
  • Li N, Parrish M, Chan TK, Yin L, Rai P, Yamada Y, Abolhassani N, Tan KB, Kiraly O, Chow VT, Engelward BP. Influenza infection induces host DNA damage and dynamic DNA damage responses during tissue regeneration. Cell Mol Life Sci. 2015 72(15):2973-2988. [PMID: 25809161]
  • Kiraly O, Gong G, Roytman MD, Yamada Y, Samson LD, Engelward BP. DNA glycosylase activity and cell proliferation are key factors in modulating homologous recombination in vivo.Carcinogenesis. 2014 Nov;35(11):2495-502. [PMID: 25155011]
  • Na L, Yin L, Thévenin D, Yamada Y, Limmon G, Chen J, Chow VT, Engelman DM, Engelward BP. Peptide targeting and imaging of damaged lung tissue in influenza-infected mice. Future Microbiol. 2013 Feb;8(2):257-69. [PMID: 23374130]
  • Yamada Y, Limmon VG, Zheng D, Li N, Li N, Yin L, Chow TKV, Chen J, Engelward PB. Major Shifts in the Spatio-Temporal Dynamics of Lung Antioxidant Enzymes During Influenza Pneumonia. PLoS One 2012; 7(2): e31494. [PMID: 22355371]
Research Fellow
Email ephyy@nus.edu.sg

 

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