HomeAboutFaculty DirectoryOOI Eng Eong

OOI Eng Eong

The global emergence of epidemic dengue is partly fueled by an incomplete understanding of the determinants of both immunity and pathogenesis. My laboratory aims to address the critical gaps in knowledge in dengue by positioning itself at the interface between clinical epidemiology, virology and immunology. We combine basic virological and virus-host interaction studies with clinical investigations and experimental medicine, including clinical trials. Specifically, we are interested in elucidating: (1) how antibodies either protect against or enhance dengue virus infection and (2) the factors that determine the outcome of infection or transmissibility and hence explain its epidemiological phenotype. By elucidating these mechanisms, we hope to contribute to the development of effective vaccines and therapeutics.

Affiliations:

  • NUS Saw Swee Hock School of Public Health (Joint)
  • Duke-NUS Medical School (Primary)
  • Department of Microbiology and Immunology, Yong Loo Lin School of Medicine 

Research Areas:

  • Dengue pathogenesis
  • Flavivirology
  • Emerging infectious diseases

Teaching Areas:

  • Dengue and emerging viruses

Academic/Professional Qualifications:

  • B.M.,B.S. (University of Nottingham)
  • Ph.D. (National University of Singapore)
  • FRCPath (UK)

Awards/Honours (Post-PhD):

  • NMRC Clinician Scientist Award (Senior Investigator) 2010
  • NMRC Clinician Scientist Award (Senior Investigator) 2014

Administrative Leadership:

  • Deputy Director, Programme in Emerging Infectious Diseases, Duke-NUS Medical School
  • Co-Director, Viral Research and Experimental Medicine Centre @SingHealth Duke-NUS

Professional/Consulting Activities:

  • Editor, Journal of General Virology

Selected Publications:

  • Chan KR, Ong EZ, Tan HC, Zhang SL, Zhang Q, Tang KF, Kaliaperumal N, Lim AP, Hibberd ML, Chan SH, Connolly JE, Krishnan M, Lok SM, Hanson BJ, Lin CN, Ooi EE (2014). Leukocyte immunoglobulin-like receptor B1 is critical for antibody-dependent dengue. Proc Natl Acad Sci USA, 111:2722-7.
  • Robinson LN, Tharakaraman K, Rowley KJ, Costa VV, Chan KR, Wong YH, Ong LC, Tan HC, Koch T, Cain D, Kirloskar R, Viswanathan K, Liew CW, Tissire H, Ramakrishnan R, Myette JR, Babcock GJ, Sasisekharan V, Alonso S, Chen J, Lescar J, Shriver Z, Ooi EE, Sasisekharan R (2015). Structure-guided design of an antibody against dengue virus directed to a non-immunodominant epitope. Cell, 162:493-504.
  • Manokaran G, Finol E, Wang C, Gunaratne J, Bahl J, Ong EZ, Tan HC, Sessions OM, Ward AM, Gubler DJ, Harris E, Garcia-Blanco M, Ooi EE (2015). Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness. Science, 350:217-21.
  • Kwek SS, Watanabe S, Chan KR, Ong EZ, Tan HC, Ng WC, Nguyen MTX, Gan ES, Zhang SL, Chan KWK, Tan JH, Sessions OM, Manuel M, Pompon J, Chua C, Hazirah S, Tryggvason K, Vasudevan SG, Ooi EE (2018). A systematic approach to the development of a safe live attenuated zika vaccine. Nat Commun, 9:1031.
  • Tharakaraman K, Watanabe S, Chan KR, Huan J, Subramaniam V, Chionh YH, Raguram A, Quinlan D, McBee M, Ong EZ, Gan ES, Tan HC, Tyagi A, Bhushan S, Lescar J, Vasudevan SG, Ooi EE*, Sasisekharan R* (2018). Rational design and characterization of a Zika virus neutralizing antibody that targets a quaternary epitope. Cell Host Microbe, 23:618-27. *Co-corresponding authors.

Professor
Tel (65) 6516 8594
Email engeong.ooi@duke-nus.edu.sg

 

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